EFFECT OF MINOCYCLINE AND MINOSCYCLINE+METFORMIN ON DIABETES-RELATED DEPRESSION

Objective: Minocycline is a second-generation tetracycline group antibiotic that acts on the central nervous system. reduces microglial activation and has anti-inflammatory, anti-apoptotic, antioxidant properties. Recently, it been proposed there bidirectional relationship between diabetes depression inflammation one of common pathways in their pathophysiology. The effects minocycline were then investigated. This study aimed to reveal alone or combination with metformin, which used treatment diabetes, diabetes-related depression. Material Method: For this purpose, establish human-like type 2 model mice, streptozotocin (STZ) (50mg/kg) was administered once day for five consecutive days after 4-week high-fat diet. Animals blood glucose levels ≥200 mg/dl considered diabetic employed experiment. (40 mg/kg), fluoxetine (20 metformin (200 mg/kg) given 7 two weeks STZ injection. After drug injections completed, an open field test determine locomotor activity forced swimming level. Result Discussion: It concluded drugs did not induce significant change activity, minocycline-metformin at least as effective treating recognized initiation antidepressant short period critical patient adherence therapy prognosis. In conclusion, antidepressant-like subchronic appear be potent classical antidepressants. mechanisms underlying minocycline's mood should broadly investigated increase our understanding unveil potential novel therapies management.